ENTROPY MEASURES FOR PLITHOGENIC SETS AND APPLICATIONS IN MULTI-ATTRIBUTE DECISION MAKING


Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.

The lentiviral protein Viral Infectivity synovex one grass Factor (Vif) counteracts the antiviral effects of host APOBEC3 (A3) proteins and contributes to persistent HIV infection.Vif targets A3 restriction factors for ubiquitination and proteasomal degradation by recruiting them to a multi-protein ubiquitin E3 ligase complex.Here, we describe a de

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A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes

Immune checkpoint blockades prescribed in the neoadjuvant setting are now under altitude sunscreen active investigation for many types of tumors, and many have shown early success.The primary tumor (PT) and tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for op

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Barite replacement boxwork in the Frasassi caves (Italy)

The Frasassi caves, located in the Sentino River Gorge in Ancona Province (Marche, Italy), contains boxwork in a small zone in the inner part of the cave system where it is closely associated with subaqueous corrosion produced by sulfuric acid speleogenesis.The boxwork consists of barite that replaces calcite spar-filled veins and limestone porosit

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